The phrase "leads off" can be substituted with various synonyms depending on the context. In a sports game, "starts" or "kicks off" could be used instead of "leads off." In a conversation or speech, "begins," "initiates," or "commences" can be utilized. When introducing a topic in writing, "opens with" or "launches" can be used in place of "leads off." Additionally, "sets the tone" and "paves the way" are suitable alternatives. In all situations, the goal is to start strongly and grab the audience's attention, making it essential to choose a synonym that effectively conveys this idea.